Oral Bioavailability Assessment

Basics and Strategies for Drug Discovery and Development

Nonfiction, Science & Nature, Science, Chemistry, Analytic, Health & Well Being, Medical, Medical Science, Pharmacology
Cover of the book Oral Bioavailability Assessment by Ayman F. El-Kattan, Mike S. Lee, Wiley
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Author: Ayman F. El-Kattan, Mike S. Lee ISBN: 9781118916933
Publisher: Wiley Publication: May 15, 2017
Imprint: Wiley Language: English
Author: Ayman F. El-Kattan, Mike S. Lee
ISBN: 9781118916933
Publisher: Wiley
Publication: May 15, 2017
Imprint: Wiley
Language: English

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.

• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.

• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

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